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Evidence-Based Dentistry: Systematic Reviews
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Chlorhexidine

The following systematic reviews are available for the topic chlorhexidine. Links to summaries of the systematic reviews are provided if available. These summaries are not developed by the ADA. In some cases, links are provided to the full-text copy of systematic reviews published in the Journal of the American Dental Association (JADA).

A meta-analysis of clinical studies on the caries-inhibiting effect of chlorhexidine treatment.
van Rijkom HM, Truin GJ, van 't Hof MA. J Dent Res 1996; 75(2): 790-5.

A systematic review on the effects of subgingival chlorhexidine gel administration in the treatment of chronic periodontitis.
Cosyn J, Sabzevar MM. J Periodontol 2005; 76(11): 1805-13.

A systematic review on the effects of the chlorhexidine chip when used as an adjunct to scaling and root planing in the treatment of chronic periodontitis.
Cosyn J, Wyn I. J Periodontol 2006; 77(2): 257-64.

Caries-inhibiting effect of preventive measures during orthodontic treatment with fixed appliances. A systematic review.
Derks A, Katsaros C, Frencken JE, van't Hof MA, Kuijpers-Jagtman AM. Caries Res 2004; 38(5): 413-20.

Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review.
Caso A, Hung LK, Beirne OR. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 99(2): 155-9.

Rinsing with chlorhexidine gluconate solution after brushing and flossing teeth: a systematic review of effectiveness.
Kolahi, J. and A. Soolari, Quintessence Int, 2006. 37(8): p. 605-12.

Chlorhexidine varnish for preventing dental caries in children, adolescents and young adults: a systematic review.
Q. Zhang, W. H. van Palenstein Helderman, M. A. van't Hof and G. J. Truin. Eur J Oral Sci. 2006. 114(6): p. 449-55.

Impact of local adjuncts to scaling and root planing in periodontal disease therapy: a systematic review.
Bonito AJ, Lux L, Lohr KN. J Periodontol 2005 Aug;76(8):1227-36.

The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: a systematic review of the literature.
Ribeiro LG, Hashizume LN, Maltz M. J Dent 2007 May;35(5): 359-70.

Interventions for preventing oral mucositis for patients with cancer receiving treatment.
Worthington HV, Clarkson JE, Eden OB. Cochrane Database Syst Rev 2007 Oct 17;(4): CD000978.

Use of chlorhexidine varnishes in preventing and treating periodontal disease. A review of the literature.
Puig Silla M, Montiel Company JM, Almerich Silla JM. Med Oral Patol Oral Cir Bucal 2008;13(4):E257-60.

 

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